SDHB Polyclonal Antibody dm-04340

SDHB Polyclonal Antibody

Catalog No dm-04340 

Isotype IgG 

Reactivity Human;Mouse;Rat;Fish 

Applications WB;IHC;IF;ELISA 

Gene Name SDHB

Protein Name Succinate dehydrogenase [ubiquinone] iron-sulfur subunit mitochondrial

Immunogen The antiserum was produced against synthesized peptide derived from the Internal region of human SDHB. AA range:131-180 

Specificity SDHB Polyclonal Antibody detects endogenous levels of SDHB protein. 

Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. 

Source Polyclonal, Rabbit,IgG 

Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. 

Dilution WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200

Concentration 1 mg/ml 

Purity ≥90% 

Storage Stability -20°C/1 year

Synonyms SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip

Observed Band 31kD

Cell Pathway Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Tissue Specificity Brain,Fibroblast,Liver, 

Function catalytic activity:Succinate + ubiquinone = fumarate + ubiquinol.,cofactor:Binds 1 2Fe-2S cluster.,cofactor:Binds 1 3Fe-4S cluster.,cofactor:Binds 1 4Fe-4S cluster.,disease:Defects in SDHB are a cause of Cowden-like syndrome [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.,disease:Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant m